Figure 1.

Treatment with 1400W, a selective iNOS inhibitor caused spatial memory improvement in cannulated non-anesthetized animals in Morris water maze during testing trials. Inhibition of inducible nitric oxide synthase by bilateral intra-hippocampal infusion of 1400W (100 μM/side) via cannulas after surgical recovery, led to significant decrease in escape latency and traveled distance (* P < 0.05) in comparison with control group (Figures 1A and 1B). The swimming speed did not change significantly in all treated animals (Figure 1C). Each bar graph shows mean ± SEM for 8 animals in each group