Table 2.
The main pharmacokinetic parameters of N-desmethyl imatinib in four groups (n = 5).
| Parameters | A | B | C | D |
|---|---|---|---|---|
| AUC(0–t) (mg·h·L−1) | 5.977 ± 1.626 | 6.335 ± 1.105 | 4.797 ± 0.602** | 5.262 ± 0.89 |
| AUC(0–∞) (mg·h·L−1) | 6.827 ± 2.595 | 6.672 ± 0.797 | 5.05 ± 0.797 | 5.545 ± 0.814 |
| MRT(0–t) (h) | 7.085 ± 1.135 | 6.573 ± 0.544 | 7.227 ± 0.525 | 7.326 ± 0.53 |
| MRT(0–∞) (h) | 9.718 ± 4.636 | 7.504 ± 0.189 | 8.397 ± 1.545 | 8.679 ± 1.301 |
| t (1/2)z (h) | 5.495 ± 3.92 | 4.083 ± 0.436 | 4.906 ± 2.093 | 5.376 ± 1.495 |
| T max (h) | 3.6 ± 0.894 | 4.0 ± 0.003 | 4.0 ± 0.005 | 3.8 ± 0.447 |
| Vz/F (kg·L−1) | 32.802 ± 10.255 | 26.843 ± 4.486 | 40.738 ± 12.777 | 43.512 ± 16.116** |
| CLz/F (L·min−1·kg−1) | 4.913 ± 1.782 | 4.552 ± 0.592 | 6.066 ± 0.992 | 5.507 ± 0.834 |
| C max (mg·L−1) | 0.678 ± 0.147 | 0.797 ± 0.073 | 0.547 ± 0.091** | 0.639 ± 0.13** |
*P < 0.05 in comparison to group A; **P < 0.05 in comparison to group B.