Table 2.
Active compounds of blood-tonifying herbs in this work and their targets of different diseases.
| Disease | TCM | Molecular | Target | Reference* |
|---|---|---|---|---|
| Regulate hemopoietic growth factor | Radix paeoniae alba | Albiflorin | PKCα | |
| Radix paeoniae alba | Paeonioflorin | IL-6, LBP, PKCα, TNF | ||
| Angelica sinensis | Ferulic acid | ADRA2A, PTGER4, SHP-2, F2, TUBB1 | ||
| Angelica sinensis | ligustilide | SOD1, TNFa | ||
| Polygonum multiflorum | Stilbene glucoside | CALM, F7, F10, F2, NQO2, PTPN1 | ||
| Rehmannia glutinosa | Catalpol | NOS2b, F2, SOD1 | ||
| Rehmannia glutinosa | Verbascoside | PKCα, F2 | ||
|
| ||||
| Regulate bone marrow stromal cell | Radix paeoniae alba | Paeonioflorin | CD14 | |
| Angelica sinensis | Ferulic acid | MAOA, MAOB, DPP-IV, ITGB3, ITGB5, MAOB, ITGAV | [15] | |
| Angelica sinensis | ligustilide | ACHEb | ||
| Polygonum multiflorum | Stilbene glucoside | DPP-IV | ||
| Rehmannia glutinosa | Catalpol | DPP-IV | ||
| Rehmannia glutinosa | Verbascoside | CAM1 | ||
|
| ||||
| Regulate hematopoietic stem cell apoptosis |
Angelica sinensis | Ferulic acid | APP, ADRB2, CDK2, DNA pol beta, MIF, PTGER2, PTGER3, RARG, PIM1, TBXAS1 | |
| Angelica sinensis | ligustilide | BAXb, Bcl-2, CASP3b | ||
| Polygonum multiflorum | Stilbene glucoside | CDK2, CCNA2, PIM1 | ||
| Rehmannia glutinosa | 5-Hydroxymethyl-furoic acid | CDK2 | [17] | |
| Rehmannia glutinosa | Catalpol | Bcl-2c, CASP3b | ||
| Rehmannia glutinosa | Verbascoside | APP | ||
*The corresponding efficacy of botanic drug has been supported by the literature.
Superscript with targets: The functional activity of the components with regard to the targets.
aDown-regulate gene. bDecrease expression or activity. cIncrease expression level or activity. dDirectly inhibit.