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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 May 2;33(7):10.1161/ATVBAHA.112.300922. doi: 10.1161/ATVBAHA.112.300922

Figure 1.

Figure 1

Statins upregulate small GTP-binding protein GDP dissociation stimulator (SmgGDS) and the effects of statins are absent in SmgGDS+/− mice. A and B, Expression of SmgGDS protein after incubating human umbilical venous endothelial cells with atorvastatin (ATOR) or pitavastatin (PITA) for 24 hours (n=3 each). C, Expression of SmgGDS protein in the aorta administered with vehicle, ATOR, or PITA in mice for 1 week (n=10 each). D, Representative Masson’s trichrome staining of the coronary artery in control (−), angiotensin II (AngII)-infused mice (no inhibitor, AngII[+]), and AngII-infused mice treated with either ATOR (AngII+ATOR, 10 mg/kg per day) or pravastatin (PRA) (AngII+PRA, 50 mg/kg per day). Medial thickening and perivascular fibrosis of the coronary arteries in SmgGDS+/+ (left) and SmgGDS+/− (right ) mice are shown. E and F, Quantitative analysis of cardiovascular intima-medial area and perivascular fibrosis area in SmgGDS+/+ and SmgGDS+/− mice treated with vehicle or statins at 2 weeks after AngII infusion (n=10). Results are expressed as mean±SEM. N.S. indicates not significant.