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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 May 2;33(7):10.1161/ATVBAHA.112.300922. doi: 10.1161/ATVBAHA.112.300922

Figure 3.

Figure 3

Small GTP-binding protein GDP dissociation stimulator (SmgGDS) upregulation by statins in human umbilical venous endothelial cell (HUVECs) is not reversed by inhibition of mevalonate pathway. A, The effect of mevalonate (200 μmol/L) on statin-induced SmgGDS upregulation in HUVECs (n=3). B, The effect of mevalonate (200 μmol/L) on statin-induced vascular endothelial growth factor (VEGF) upregulation in HUVECs (n=3). C, The effect of farnesyl pyrophosphate (FPP, 10 μmol/L) and geranylgeranyl pyrophosphate (GGPP, 10 μmol/L) on statin-induced SmgGDS upregulation in HUVECs (n=3). D, Expression of SmgGDS protein after incubating HUVECs with Rho-kinase inhibitor hydroxyfasudil (HF) for 24 hours (n=3). Results are expressed as mean±SEM. N.S. indicates not significant.