Table 3.

Scoring system for CNSVSS, POMS, and Chalder scales.

Scales and scoring	Definition	Units and normal range	Explanation
CNS vital signs
Cognitive flexibility	Measure of frontal lobe functioning	Milliseconds Age-dependent	A higher value represents a higher level of functioning
Reaction time	Average measure of two distinct attention components	Milliseconds Age-dependent	A higher score represents a longer reaction time
Complex attention	Combined measure of simple, choice, and shifting attention elements	Milliseconds Age-dependent	A higher score represents a higher level of attention
Working memory	Measures well-known “2-back” working memory	Milliseconds Age-dependent	A higher score represents a higher level of working memory
Sustained attention	Combined measure of three cascading attention tests each slightly more difficult than the previous.	Milliseconds Age-dependent	A higher score represents a higher level of sustained attention
Executive functioning	Measure of how well a subject deals with making correct decisions in a shifting rule and target environment	Milliseconds Age-dependent	A higher score represents a higher level of executive functioning
Processing speed	Scores how well a subject deals with moving across a keyboard based on keys and stimuli	Milliseconds Age-dependent	A higher score represents a longer processing speed
Average standard score	Composite score of overall cognitive function	Milliseconds Age-dependent	A higher score represents a higher level of overall cognitive function
POMS scoring
Tension	Assess transient, distinct mood state of tension	0–4 Likert scale No normal range	A higher score indicates that subject tends to be fidgety, restless, and quickly frustrated with people
Depression	Assess transient, distinct mood state of depression	0–4 Likert scale No normal range	A higher score indicates that subject feels complete and utter loss of hope and unable to carry out normal activities
Anger	Assess transient, distinct mood state of anger	0–4 Likert scale No normal range	A higher score indicates the subject's intensity of expressing anger at a particular time
Vigor	Assess transient, distinct mood state of vigor	0–4 Likert scale No normal range	A higher score indicates that the subject is feeling cheerful, lively, alert, active, and carefree
Fatigue	Assess transient, distinct mood state of fatigue	0–4 Likert scale No normal range	A higher score indicates more severe fatigue, fatigue distress, or impact on activities of daily living
Confusion	Assess transient, distinct mood state of confusion	0–4 Likert scale No normal range	A higher score indicates that subject tends to feel mixed up and confused either with instructions or surrounding environment
Total mood disturbance	Composite score of distressed mood states	0–4 Likert scale No normal range	A higher score indicates anxiety, emotional suppression, and psychological distress
Chalder scales
Total physical	Self-rated 8-question scale of physical symptoms	0–3 Likert scale No normal range	High scores indicate an increased risk for cardiovascular diseases
Total mental	Self-rated 6-question scale regarding mental fatigue	0–3 Likert scale No normal range	High scores indicate presence of anxiety and depression