Table 4.

Chemopreventive effect of palmatine against DMBA and croton oil induced skin carcinogenesis in mice.

Treatment	Final body weight (g)	Number of papilloma	Tumor size	Average latency perioda
Group 1	37.56 ± 5.43*
Group 2	22.75 ± 11.24	10.16 ± 5.03	2.06 ± 0.37	10.10 ± 5.17
Group 3	36.96 ± 6.31*
Group 4	38.87 ± 9.67*	1.50 ± 1.04*	0.90 ± 0.29*	15.73 ± 0.58*
Group 5	40.12 ± 6.89*	0.83 ± 0.75*	0.56 ± 0.22*	18.16 ± 0.55*

Values with * superscripts were significant (P < 0.05) in comparison with Group 2.

^aThe lag between the application of the promoting agent and the appearance of 50% of tumors was determined. Average latency period = ∑fx/n; f is the number of tumors appearing each week; x is the numbers of weeks; and n is the total number of tumors.