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Resistant C57Bl/6 (B6) mice were backcrossed with nephropathic FVB/N (FVB) mice to produce diabetic progeny (diabetic F1) which were analyzed for histopathologic features of nephropathy and genotyped for over 100 single nucleotide polymorphisms. A single locus on chromosome 8 showed a major linkage to the combined nephropathy histology score suggesting a major contribution of this single gene to the development of nephropathy in FVB diabetic mice.
