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Parameters for DMPC clearance and cholesterol efflux by apoA-I variants.
| DMPC clearance |
Cholesterol efflux (BHK/ABCA1) |
|||||
|---|---|---|---|---|---|---|
| Relative | Relative | |||||
| Relative | Km | Relative | Km | |||
| catalytic | catalytic | |||||
| Vmax | (µg/ml) | Vmax | (µg/ml) | |||
| efficiency | efficiency | |||||
| Wild-type | 1.0 ± 0.1 | 62 ± 14 | 1.0 | 1.0 ± 0.1 | 1.5 ± 0.5 | 1.0 |
| Δ191–220 | 1.1 ± 0.1 | 384 ± 167 | 0.17 | 1.1 ± 0.2 | 4.3 ± 1.6 | 0.40 |
The data for Δ223–243 apoA-I could not be fitted with the Michaelis-Menten equation.
