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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Neuron. 2013 Jun 13;79(1):10.1016/j.neuron.2013.04.039. doi: 10.1016/j.neuron.2013.04.039

Figure 4. Disconnection of the thalamo-striatal pathway confirms parafascicular involvement action-outcome learning in the posterior dorsomedial striatum.

Figure 4

(A) Rat Nissl-stained sections showing anatomical disconnection through unilateral DMS and Pf NMDA excitotoxic lesions (sham and contralateral groups shown). (B–H) Mean or % baseline rate of lever pressing (±(1 SEM) during: (B) acquisition of initial action-outcome contingencies averaged over levers; (C) outcome devaluation testing; (D) acquisition of contingency degradation; (E) contingency degradation testing; (F) acquisition of the reversed contingencies; (G) outcome devaluation testing of the reversed contingencies; (H) reinstatement of reversed contingencies; (I) Minimal (black) and maximal (grey) lesions in the Pf and posterior DMS. Lesion side was counterbalanced; and (J) Reversal acquisition and (K) outcome devaluation after Pf-aDMS disconnection. See also Figure S1.