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. Author manuscript; available in PMC: 2014 Aug 30.
Published in final edited form as: Gerontology. 2013 Aug 30;59(6):10.1159/000354170. doi: 10.1159/000354170

Figure 1.

Figure 1

TIA-1, TDP-43 and many other RBPs reside in the nucleus under basal conditions. Their nuclear functions vary, but RBPs act in part to facilitate RNA transcription and to regulate RNA splicing. Stress causes these nuclear RBPs to leave the nucleus. In the cytoplasm, the RBPs bind stalled, free mRNA and aggregate to form SGs primarily through the glycine rich domains and secondarily by other domains. The process of SG formation is reversible, but prolonged stress leads to maturation and incorporation of other proteins and post-translational modifications. Mature SGs interact with P-bodies, the autophagic and apoptotic systems.