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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: Nature. 2009 Oct 29;461(7268):10.1038/nature08534. doi: 10.1038/nature08534

Figure 4.

Figure 4

Epigenetics changes during reprogramming of epiblast cells. (a) Female cEpi exhibit uniform accumulation of H3K27me3 associated with the inactive X (white arrowhead), which is gradually lost from individual cells during culture and finally lost in rESC. Scale bar: 20 μm (b) Changes in DNA methylation of Stella and Rex1 during reprogramming of epiblast. Although Stella and Rex1 are repressed in epiblast cells, these loci are initially unmethylated; they undergo DNA methylation transiently in cEpi and stably in EpiSC. Reprogramming to form rESC results in the loss of DNA methylation.