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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: Nature. 2009 Oct 29;461(7268):10.1038/nature08534. doi: 10.1038/nature08534

Figure 5.

Figure 5

Contribution of rESC to chimeras. (a) Progeny derived from chimera with rESC showing germline transmission indicated by black arrow. (b) E6.5 chimera with ROSA-lacZ rESC: Note contribution of early passage rESC both to the epiblast and to the extraembryonic ectoderm (ExE), a derivative of trophectoderm cells. (c) E6.5 chimera derived with ROSA-lacZ ESC; Note contribution predominantly to the epiblast. (d) Schematic representation of reprogramming of cEpi and EpiSC to rESC. Note the epigenetic and transcriptional changes during reprogramming of cEpi and EpiSC.