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The distribution of the top four phyla grouped at each time point. (A) In the control subjects, no significant change from baseline was observed in any of the phyla after rhinovirus (RV) infection. (B) The response to RV in the chronic obstructive pulmonary disease (COPD) cohort was not uniform, but there was a significant increase from baseline in Proteobacteria on Day 15 after RV inoculation (P = 2.2 × 10–16).
