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. 2013 Nov 1;188(9):1137–1146. doi: 10.1164/rccm.201304-0803OC

Figure 2.

Figure 2.

S100A8/A9 expression correlates with active disease and lung inflammation in humans with active tuberculosis (ATB). Formalin-fixed paraffin embedded lung sections from patients with ATB (A) were stained with hematoxylin and eosin or with antibodies specific for S100A8 (red) and MPO (green). Three representative human ATB samples (A) are shown (top, hematoxylin and eosin, original magnification ×100; bottom, ×200). Immunohistochemistry, 4 × 4 mosaic (top, ×200 original magnification; bottom, ×200) (A). S100A8/A9 (B), induced protein-10 (IP-10) (C), and keratinocyte chemoattractant (KC) (D) protein levels were measured in serum collected from healthy control subjects (HC), ATB, latent TB infection (LTBI), and patients with rheumatoid arthritis (RA) using ELISA or Luminex assays. Linear correlation analysis of S100A8/9 protein levels and KC (E), S100A8/A9 protein levels and neutrophils in peripheral blood (F), and S100A8/A9 levels and lung damage score (G) in HCs (blue triangles), patients with ATB (red triangles), and patients with LTBI (green triangles) was performed using GraphPad Prism (GraphPad Software, Inc., La Jolla, CA). The data points represent the mean (±SD) of values from 15 HCs, 17 ATB, 8 LTBI, and 33 RA patients (B–G). **P ≤ 0.005, ***P ≤ 0.0005. ns = not significant.