TABLE 2.
COX PROPORTIONAL HAZARDS MODEL FOR CLAD
| |
Univariable |
Multivariable* |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |||
| DAD |
3.09† |
1.95 |
4.88 |
2.96† |
1.86 |
4.72 |
| AR (≥grade A2) |
1.52† |
1.22 |
1.89 |
1.32‡ |
1.03 |
1.69 |
| LB |
1.33† |
1.17 |
1.51 |
1.19‡ |
1.03 |
1.37 |
| OP |
1.34§ |
1.09 |
1.65 |
|
|
|
| Age >70 |
1.69 |
0.86 |
3.32 |
|
|
|
| Male sex |
1.24 |
0.90 |
1.71 |
|
|
|
| Single lung transplant |
1.35 |
0.99 |
1.85 |
1.39‡ |
1.01 |
1.91 |
| Dx: CF |
0.50 |
0.19 |
1.36 |
|
|
|
| Dx: IPF |
0.85 |
0.62 |
1.17 |
|
|
|
| Dx: PH |
1.51 |
0.77 |
2.97 |
|
|
|
| Dx: COPD |
1.07 |
0.77 |
1.50 |
|
|
|
| Time of Tx: first tertile |
0.68 |
0.43 |
1.07 |
|
|
|
| Time of Tx: second tertile | 1.00 | 0.66 | 1.52 | |||
Definition of abbreviations: AR = acute rejection; CF = cystic fibrosis; CI = confidience interval; CLAD = chronic lung allograft dysfunction; COPD = chronic obstructive pulmonary disease; DAD = diffuse alveolar damage; HR = hazard ratio; IPF = idiopathic pulmonary fibrosis; LB = lymphocytic bronchiolitis; OP = organizing pneumonia; PH = pulmonary hypertension; Tx = transplantation.
Time of Tx: first tertile = before 9/1/05; second tertile = 9/1/05 to 2/13/08. Reference group = after 2/13/08.
*
Multivariable model includes only the variables listed: DAD, AR, LB, single lung transplant.
†
P < 0.001.
‡
P < 0.05.
§
P < 0.01.