TABLE 3.
CAUSE-SPECIFIC PROPORTIONAL HAZARDS MODEL FOR CLAD PHENOTYPES AMONG DOUBLE LUNG TRANSPLANT RECIPIENTS
| |
Univariable |
Multivariable* |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |||
| RAS |
|
|
|
|
|
|
| DAD |
6.42† |
3.31 |
12.45 |
6.46† |
3.33 |
12.54 |
| AR (≥grade A2) |
1.74‡ |
1.10 |
2.73 |
1.77‡ |
1.12 |
2.81 |
| LB |
1.36 |
0.99 |
1.86 |
|
|
|
| OP |
1.47‡ |
1.04 |
2.07 |
|
|
|
| BOS |
|
|
|
|
|
|
| DAD |
— |
— |
— |
— |
— |
— |
| AR (≥grade A2) |
1.92§ |
1.20 |
3.07 |
1.92§ |
1.20 |
3.07 |
| LB |
1.50‡ |
1.08 |
2.08 |
|
|
|
| OP | 1.14 | 0.66 | 1.95 | |||
Definition of abbreviations: AR = acute rejection; BOS = bronchiolitis obliterans syndrome; CI = confidence interval; CLAD = chronic lung allograft dysfunction; DAD = diffuse alveolar damage; HR = hazard ratio; LB = lymphocytic bronchiolitis; OP = organizing pneumonia; RAS = restrictive allograft syndrome.
*
Multivariable model includes only the injury patterns listed. Includes double lung transplants only.
†
P < 0.001.
‡
P < 0.05.
§
P < 0.01.