TABLE 4.
COX PROPORTIONAL HAZARDS MODEL FOR ALLOGRAFT MORTALITY
| |
Univariable |
Multivariable* |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |||
| DAD |
3.37† |
2.57 |
4.42 |
2.25† |
1.67 |
3.03 |
| AR (≥grade A2) |
1.32‡ |
1.10 |
1.59 |
|
|
|
| LB |
1.23† |
1.13 |
1.33 |
|
|
|
| OP |
1.47† |
1.25 |
1.72 |
1.25§ |
1.05 |
1.48 |
| CLAD |
4.14† |
3.01 |
5.69 |
3.27† |
2.32 |
4.60 |
| Age >70 |
1.76 |
0.98 |
3.17 |
2.08§ |
1.09 |
3.98 |
| Male sex |
1.24 |
0.93 |
1.66 |
|
|
|
| Single lung transplant |
1.19 |
0.90 |
1.58 |
|
|
|
| Dx: CF |
0.21§* |
0.05 |
0.85 |
|
|
|
| Dx: IPF |
1.14 |
0.86 |
1.51 |
|
|
|
| Dx: PH |
1.33 |
0.70 |
2.51 |
|
|
|
| Dx: COPD |
1.04 |
0.77 |
1.40 |
|
|
|
| Time of Tx: first tertile |
1.35 |
0.87 |
2.09 |
|
|
|
| Time of Tx: second tertile | 1.46 | 0.95 | 2.24 | |||
Definition of abbreviations: Allograft Mortality = death or retransplant; AR = acute rejection; CF = cystic fibrosis; CI = confidence interval; CLAD = chronic lung allograft dysfunction; COPD = chronic obstructive pulmonary disease; DAD = diffuse alveolar damage; HR = hazard ratio; IPF = idiopathic pulmonary fibrosis; LB = lymphocytic bronchiolitis; OP = organizing pneumonia; PH = pulmonary hypertension; Tx = transplantation.
Time of Tx: first tertile = before 9/1/05; second tertile = 9/1/05 to 2/13/08. Reference group = after 2/13/08.
*
Multivariable model includes only the variables listed: DAD, OP, CLAD, age greater than 70.
†
P < 0.001.
‡
P < 0.01.
§
P < 0.05.