TABLE 4.

MULTIVARIATE ANALYSIS IDENTIFIED HISPANIC ETHNICITY AS A RISK FACTOR FOR GENE METHYLATION^*

Variable	Odds Ratio (95% Confidence Interval)	P Value
Age, 10 yr	1.09 (1.03–1.16)	0.0053
Male sex	1.38 (1.23–1.55)	3.8 × 10−8
Current smoker	0.81 (0.72–0.90)	1.7 × 10−4
Pack-years, 10	1.01 (0.98–1.04)	0.48
Chronic mucous hypersecretion	1.11 (0.99–1.24)	0.082
Body mass index ≥ 25	1.01 (0.90–1.13)	0.90
Hispanic ethnicity†	1.18 (1.05–1.32)	0.007

^*n = 1,540.

^†Compared with non-Hispanic whites.