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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: J Med Chem. 2012 Oct 15;55(20):10.1021/jm301160h. doi: 10.1021/jm301160h

Table 1.

Activities of esters and amides against PfNMTa

graphic file with name emss-55735-t0011.jpg

No. Y R2 IC50 (μM)
2 COO Et 16.5
3 COO Ph 24.4
4 COOCH2 Ph 0.27
5 COOCH2 α-napthyl 1.4
6 COOCH2 cyclo-hex 9.7
7 COO(CH2)2 Ph 4.1
8 COO(CH2)3 Ph 36.2
9 CONH i-Pr >200
10 CONH cyclo-hex >100
11 CONH Ph 28.8
12 CONHCH2 Ph 13.0
13 CONHCH2 α-napthyl 2.3
a

The IC50(PfNMT) values were averaged from two independent dose-response curves, the standard deviation was within 30% of the resulting values.