Behavior tests. To screen for an effect of G-F-DD in the 6-OHDA rat model, several behavior tests were performed. Amphetamine-induced rotations were performed before lesion, 2 weeks after lesion and 6 weeks after lesion to determine progressive behavior impairments (a). At the end of the experiment, the effect of G-F-DD on spontaneous motor behavior was analyzed using forelimb asymmetry test (b) and forelimb akinesia test (c). In the forelimb akinesia test, both forehand and backhand adjustments were measured. One-way ANOVA with Bonferroni multiple comparison test. (n = 10) *P < 0.05, **P < 0.01. DD, destabilizing domains.