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. 2013 Aug 20;21(12):2236–2246. doi: 10.1038/mt.2013.178

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Copyright © 2013 The American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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NOX-D20 binds to C5 but does not inhibit complement-mediated hemolysis. SPR measurement of NOX-D20 binding to human (a) C5a, (b) C5a(desArg), and (c) C5. Kinetic rate constants k_a and k_d are shown as mean ± SEM. Data are representative for at least three individual measurements. (d) Human serum pretreated with NOX-D20 (black squares) or C5-binding aptamer C5C6 (black triangles) was incubated with opsonized sheep erythrocytes. Hemolysis was quantified by photometric measurement of hemoglobin in the supernatant at 405 nm. Normalized data representative for three independent experiments is shown. RU, response units.