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NOX-D20 suppresses proinflammatory mediator release in CLP-induced sepsis. Cytokine and chemokine concentrations in (a) peritoneal lavage (PL) and (b) serum were determined 18 hours after CLP surgery and NOX-D20 or vehicle injection. Mean ± SEM for n = 7–10 mice per group is shown. For statistical analysis, one-way analysis of variance and Dunnett's comparison was performed on log-transformed values (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001).
