Figure 2. Clustering of changes in gene expression in Control and Aβ flies.

(a–j). Clustering of gene expression changes in Control (black) and AD (red) using Mfuzz. Bold lines represent cluster centroids, thin lines are average expression profiles for all cluster members plotted against equivalent time points (a–e) based on day (days 3, 10 and 20 for both Aβ and control flies, all approximately 100% survival) and (f–j) based on % survival of the flies (days 3, 21 and 25 (Aβ flies) or days 3, 56 and 68 (control flies), corresponding to 100%, 80% and 20% survival in each case).