Table 3. Sperm from folate-deficient males had differential methylation in comparison with folate-sufficient males at sites associated with cancer and chronic human diseases.

Diseases	No. of genes associated	Genes
Cancers (breast, colorectal, pancreatic, kidney, leukaemia)	18	Abcg2, Bcl2, Tlx1, Ugt1a1, Ugt1a9, Arpc1a, Aff3, Cdc73,Cenpe, Ehmt1, Gstt2, Folh1, Mtus1, Nme1, Slit2, Tyms, Whsc1l1, Nr4a3
Diabetes type I	3	Aff3, Tnfsf8, Ets1
Diabetes type II	3	Nkx2-2, Uts2, Cyp2e1
Autoimmune diseases (multiple sclerosis, lupus, arthritis)	6	Bcl2, Cd44, Ebf1, Oaz1, Ets1, Gypa
Neurological disorders (neural tube defects, Alzheimer’s disease, Huntington’s disease)	10	Cep290, Cckar, Clock, Csf1, Cyp2e1, Htt, Lrrk2, Zdhhc15, Ube3a, Tyms
Psychological disorders (autism, schizophrenia)	7	Cckar, Clock, Cyp2e1, Foxp2, Htt, Pnoc, Ube3a