Table 2.

Relationship between SNP linkage disequilibrium with rs3764650 and association with ABCA7 expression. The linkage disequilibrium between rs3764650 (r²) and each of the other SNPs was determined by using SNAP (http://www.broadinstitute.org/mpg/snap/ldsearch.php). The association between each individual SNP and ABCA7 expression was determined by linear regression analyses that included AD status, age, sex and the SNP in a dominant model. The rationale for including each SNP is noted in the comment column.

SNP	r2 with rs3764650	Standard Beta Coefficient	P-Value	Comment (reference)
rs3764650	1.000	−0.402	0.001	AD GWAS [15, 31]
rs4147914	0.584	−0.296	0.021	Exonic SNP
rs3752229	0.541	−0.296	0.028	Associates with ABCA7 expression in brain [2]
rs7251792	0.245	0.161	0.209	Associates with ABCA7 expression in monocytes [43]
rs3752246	0.230	−0.231	0.066	Non-synonymous exonic SNP [31]
rs757232	0.173	−0.170	0.174	Associates with ABCA7 expression in brain [2]
rs4147930	0.166	−0.190	0.138	Exonic SNP
rs2279796	0.036	0.123	0.354	Associates with ABCA7 expression in monocytes [43]
rs7247087	0.007	0.169	0.171	Associates with ABCA7 expression in brain [2]
rs12710103	0.006	0.037	0.772	Associates with ABCA7 expression in monocytes [43]