Figure 5.

Maximum-likelihood tree of PKRs using the protein kinase domains of PKRs from the five dipteran species described in Figure 2. The tree was rooted using a guanylyl cyclase receptor GI22298 from D. mojavensis. Branches with maximum-likelihood support values <0.8 have been collapsed to polytomies. The C. quinquefasciatus gene CPIJ006878 has been placed within the clade it presumably belongs to, though it lacks the protein kinase region used for alignment. The D. mojavensis OR1 ortholog is not annotated in FlyBase, but EST evidence supports its presence (160). Clades are named after their characterized ligands, if known.