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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: J Med Chem. 2012 Apr 3;55(7):10.1021/jm300040p. doi: 10.1021/jm300040p

Scheme 1. Synthetic pathway to compound 1a.

Scheme 1

aReagents and conditions: (i) PTSA·H2O, toluene, reflux, 16 h; (ii) Ph2O, reflux, 1 h; (iii) SOCl2, DMF, 80 °C, 1 h; (iv) NaSH, DMF, reflux, 4 h; (v) 3-bromopropanenitrile, K2CO3, DMF, 110 °C, 1 h; then, HCl 2 N in Et2O.