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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: J Med Chem. 2012 Apr 3;55(7):10.1021/jm300040p. doi: 10.1021/jm300040p

Scheme 2. Synthetic pathways to derivatives 7-11 and 20-24a.

Scheme 2

aReagents and conditions: (i) 140 °C, 1 h; (ii) Ph2O, reflux, 2 h; (iii) NaH, N,N-dimethylacetamide, 120 °C, 20 min; (iv) POCl3, 110 °C, 20 min; (v) 3-mercaptopropanenitrile, K2CO3, THF, reflux, 4 h.