Table 1.
Joint linkage-association analysis of serum uric acid (Empirical genome-wide significance: p < 1.3 × 10−7).
| Gene | SNPa | Coordinates (bp) | MGAb (p-value) | JLAc (p-value) | Minor allele/frequency |
|---|---|---|---|---|---|
| SLC2A9d | rs6832439 | 9924319 | 6.0 × 10−9 | 2.7 × 10−8 | A/0.36 |
| SLC2A9 | rs13131257 | 9981889 | 2.0 × 10−8 | 8.1 × 10−8 | T/0.36 |
| SLC2A9 | rs737267 | 9934744 | 4.2 × 10−8 | 1.7 × 10−7 | A/0.38 |
| SLC2A9 | rs6449213 | 9994215 | 1.6 × 10−6 | 5.7 × 10−6 | C/0.22 |
| CNTN4e | rs7652782 | 2821616 | 3.4 × 10−4 | 7.1 × 10−7 | A/0.06 |
| CNTN4 | rs6786387 | 2822150 | 2.6 × 10−4 | 7.6 × 10−7 | A/0.03 |
| CNTN4 | rs6786174 | 2982630 | 6.1 × 10−4 | 1.2 × 10−6 | C/0.08 |
| CNTN4 | rs17586876 | 2964182 | 1.3 × 10−3 | 2.0 × 10−6 | G/0.09 |
SNP, Single Nucleotide Polymorphism.
MGA, Measured Genotype Analysis.
JLA, Joint linkage association analysis.
SLC2A9: solute carrier protein 2 family, member 9.
CNTN4: Contactin 4.