Table 3.
Solute carrier protein 2 family, member 9 (SLC2A9) SNPs (chromosome 4) associated with cardiovascular or renal disease risk factors.
Trait | SNPb | MGAc (p-value) | SNP coordinates | Minor/major allele | Minor allele frequency | Effect size(%)d |
---|---|---|---|---|---|---|
Body weight | rs938553 | 5.5 × 10−6 | 9925526 | A/G | 0.12 | 2.8 |
BMI | rs10003001 | 9.8 × 10−4 | 9984475 | A/G | 0.07 | 2.1 |
rs10008035 | 9.1 × 10−4 | 9999335 | A/C | 0.13 | 2.0 | |
rs938553 | 7.3 × 10−4 | 9925526 | A/G | 0.12 | 2.3 | |
Waist circumference | rs10003001 | 5.0 × 10−4 | 9984475 | A/G | 0.07 | 2.2 |
rs10008035 | 8.0 × 10−4 | 9999335 | A/C | 0.13 | 2.0 | |
rs938553 | 2.0 × 10−4 | 9925526 | A/G | 0.12 | 2.6 | |
Albumin/creatinine ratio | rs1014290 | 4.0 × 10−4 | 10001861 | G/A | 0.33 | 2.1 |
rs10805346 | 6.0 × 10−4 | 9920347 | A/G | 0.41 | 2.0 | |
rs13129697 | 3.0 × 10−4 | 9926967 | C/A | 0.48 | 2.2 | |
rs7660895 | 6.0 × 10−4 | 9985445 | A/G | 0.46 | 2.0 | |
Total antioxidant status | rs6832439 | 1.4 × 10−6 | 9924319 | A/G | 0.36 | 2.9 |
rs737267 | 1.4 × 10−6 | 9934744 | A/C | 0.38 | 2.9 |
aEmpirical significance based on number of SNPs analyzed in SLC2A9 gene (p < 1.4 × 10−3).
SNP, Single Nucleotide Polymorphism.
MGA, Measured Genotype Analysis.
Proportion of the residual phenotypic variance that is explained by the minor allele of the SNP.