Table 3.
Association of SNPs with fasting serum lipid levels*.
| SNP | rs780094 | rs2228603 | rs1213785 | rs4240624 | rs738409 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect allele | T | T | C | A | G | ||||||||
| Other allele | C | C | T | G | C | ||||||||
| Nearest gene | GCKR | NCAN | LYPLAL1 | PPP1R3B | PNPLA3 | ||||||||
| Patients With NAFLD | |||||||||||||
| Genotypes | TT N=129 |
CT N=352 |
CC N=247 |
− T N=114 |
CC N=583 |
CC N=449 |
CT N=207 |
TT N=27 |
AA N=575 |
− G N=107 |
GG N=47 |
GC N=244 |
CC N=411 |
| Total-C, mg/dL (mean) | 197.6 | 189.4 | 191.0 | 178.4 | 194.7 | 192.8 | 189.6 | 191.5 | 192.4 | 192.7 | 180.6 | 190.1 | 194.7 |
| SE | 3.9 | 2.1 | 2.6 | 3.6 | 1.7 | 1.9 | 2.7 | 6.9 | 1.7 | 3.8 | 5.9 | 2.5 | 2.0 |
| p-value* | 0.11 | 0.0002 | 0.58 | 0.96 | 0.03 | ||||||||
| LDL-C, mg/dL (mean) | 109.0 | 106.2 | 108.2 | 100.2 | 109.2 | 108.0 | 105.8 | 108.7 | 107.9 | 108.2 | 98.5 | 107.8 | 108.8 |
| SE | 3.5 | 1.8 | 2.2 | 3.1 | 1.5 | 1.7 | 2.3 | 5.8 | 1.5 | 3.2 | 5.3 | 2.2 | 1.7 |
| p-value* | 0.68 | 0.009 | 0.80 | 0.96 | 0.16 | ||||||||
| HDL-C, mg/dL (mean) | 46.8 | 45.9 | 46.0 | 45.3 | 46.3 | 46.6 | 44.9 | 48.3 | 46.2 | 47.4 | 46.1 | 45.8 | 46.5 |
| SE | 0.9 | 0.6 | 0.7 | 0.9 | 0.4 | 0.5 | 0.7 | 1.9 | 0.5 | 1.0 | 1.5 | 0.6 | 0.6 |
| p-value* | 0.13 | 0.47 | 0.73 | 0.41 | 0.38 | ||||||||
| Triglycerides§, mg/dL (mean) | 213.3 | 198.8 | 188.6 | 166.6 | 205.4 | 198.3 | 202.4 | 193.0 | 201.0 | 187.7 | 175.7 | 186.1 | 209.3 |
| SE | 11.6 | 7.6 | 9.8 | 8.2 | 6.3 | 6.1 | 11.4 | 36.7 | 6.5 | 11.9 | 14.7 | 6.3 | 8.2 |
| p-value | 0.04 | 0.004 | 0.64 | 0.78 | 0.08 | ||||||||
| Patients Without NAFLD | |||||||||||||
| Genotypes | TT N=49 |
CT N=156 |
CC N=122 |
− T N=31 |
CC N=295 |
CC N=208 |
CT N=103 |
TT N=8 |
AA N=262 |
− G N=55 |
GG N=5 |
GC N=103 |
CC N=218 |
| Total-C, mg/dL (mean) | 189.0 | 183.8 | 184.7 | 189.1 | 184.6 | 186.0 | 183.4 | 192.8 | 185.5 | 183.7 | 192.0 | 178.8 | 187.8 |
| SE | 6.2 | 3.2 | 3.7 | 6.1 | 2.4 | 2.9 | 3.6 | 14.6 | 2.6 | 5.1 | 26.4 | 3.7 | 2.8 |
| p-value* | 0.62 | 0.62 | 0.70 | 0.72 | 0.15 | ||||||||
| LDL-C, mg/dL (mean) | 106.1 | 106.2 | 105.9 | 106.5 | 106.0 | 107.2 | 104.3 | 111.5 | 106.3 | 106.3 | 111.6 | 100.4 | 108.5 |
| SE | 5.1 | 2.9 | 3.3 | 6.1 | 2.1 | 2.6 | 3.1 | 13.4 | 2.3 | 4.6 | 26.4 | 3.3 | 2.5 |
| p-value* | 0.90 | 0.92 | 0.56 | 0.89 | 0.15 | ||||||||
| HDL-C, mg/dL (mean) | 52.9 | 50.2 | 50.9 | 53.1 | 50.5 | 50.6 | 51.4 | 53.3 | 51.1 | 49.6 | 56.8 | 48.7 | 51.6 |
| SE | 1.6 | 0.9 | 1.1 | 2.0 | 0.7 | 0.9 | 1.1 | 5.4 | 0.8 | 1.4 | 4.9 | 1.1 | 0.8 |
| p-value* | 0.52 | 0.44 | 0.53 | 0.44 | 0.13 | ||||||||
| Triglycerides§, mg/dL (mean) | 145.5 | 138.3 | 139.7 | 147.6 | 140.4 | 140.0 | 140.5 | 139.6 | 140.5 | 139.3 | 116.8 | 148.1 | 138.3 |
| SE | 12.2 | 5.8 | 5.4 | 13.2 | 4.0 | 4.5 | 7.0 | 36.5 | 4.4 | 7.4 | 16.7 | 7.4 | 4.6 |
| p-value | 0.74 | 0.61 | 0.83 | 0.59 | 0.39 | ||||||||
| All Patients With and Without NAFLD | |||||||||||||
| Genotypes | TT N=186 |
CT N=522 |
CC N=384 |
− T N=155 |
CC N=928 |
CC N=696 |
CT N=325 |
TT N=39 |
AA N=883 |
− G N=172 |
GG N=54 |
GC N=370 |
CC N=664 |
| Total-C, mg/dL (mean) | 195.1 | 187.1 | 188.8 | 180.1 | 191.0 | 190.2 | 187.4 | 191.0 | 189.8 | 190.3 | 181.1 | 186.8 | 191.8 |
| SE | 3.3 | 1.8 | 2.1 | 3.1 | 1.4 | 1.6 | 2.2 | 6.0 | 1.4 | 3.0 | 5.7 | 2.1 | 1.6 |
| p-value* | 0.12 | 0.003 | 0.58 | 0.92 | 0.03 | ||||||||
| LDL-C, mg/dL (mean) | 108.1 | 105.6 | 107.3 | 101.2 | 107.9 | 107.4 | 105.2 | 108.6 | 107.0 | 108.0 | 99.9 | 105.8 | 108.2 |
| SE | 2.8 | 1.5 | 1.8 | 2.7 | 1.2 | 1.4 | 1.8 | 5.1 | 1.2 | 2.6 | 5.2 | 1.8 | 1.4 |
| p-value* | 0.75 | 0.02 | 0.61 | 0.85 | 0.12 | ||||||||
| HDL-C, mg/dL (mean) | 48.6 | 47.3 | 47.6 | 46.7 | 47.8 | 47.9 | 47.1 | 49.2 | 47.7 | 48.3 | 46.9 | 46.7 | 48.3 |
| SE | 0.8 | 0.5 | 0.5 | 0.9 | 0.4 | 0.4 | 0.6 | 1.9 | 0.4 | 0.8 | 1.5 | 0.5 | 0.5 |
| p-value* | 0.21 | 0.24 | 0.97 | 0.66 | 0.03 | ||||||||
| Triglycerides§, mg/dL (mean) | 193.5 | 178.5 | 172.1 | 162.4 | 182.7 | 179.0 | 181.0 | 180.6 | 181.1 | 171.3 | 167.3 | 173.7 | 184.2 |
| SE | 9.0 | 5.5 | 6.7 | 6.9 | 4.4 | 4.5 | 7.9 | 28.1 | 4.4 | 8.2 | 13.2 | 4.9 | 5.6 |
| p-value | 0.08 | 0.18 | 0.78 | 0.98 | 0.63 | ||||||||
*
Age-, sex-, and lipid lowering medication-adjusted mean and standard error are presented for each genotype group.
§
Log-transformed for analysis and back-transformed for presentation. C = cholesterol