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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: J Immunol. 2013 Nov 11;191(12):10.4049/jimmunol.1301169. doi: 10.4049/jimmunol.1301169

Fig 6. B cells in the IRF8 deficient mice are hypersensitive to antigen stimulation.

Fig 6

A) B cells were isolated from spleens of IRF8+/+HEL-Tg and IRF8−/−HEL-Tg mice, stained with CFSE dye and incubated with increasing concentrations of HEL. Four days later, the cells were analyzed by FACS. B) The isolated B cells from IRF8+/+HEL-Tg and IRF8−/−HEL-Tg mice were treated with increasing concentrations of HEL. The treated cells were lysed after 12h. Western Blot analysis was used to detect the expression of c-Myc, cyclin D2 and IRF4. The results are representatives of at least three independent experiments.