Table 3.
Neural activity during accurate retrieval of relational information and item information in normal control and aMCI participants
MNI Coordinates |
||||||||
---|---|---|---|---|---|---|---|---|
Contrast | Region of Activation | Hemisphere | BA | x | y | z | t | k |
Normal Control | ||||||||
Relational > Item | Inferior Parietal Lobule | R | 40 | 60 | −28 | 20 | 6.68 | 148 |
Angular Gyrus | L | 39 | −48 | −62 | 14 | 6.33 | 69 | |
Parahippocampal Cortex | R | 36 | 30 | −34 | −8 | 4.34 | 71 | |
Item > Relational | Inferior Frontal Gyrus | R | 47 | 40 | 22 | −6 | 4.34 | 53 |
Superior Frontal Gyrus | R | 10 | 30 | 60 | 8 | 4.18 | 45 | |
aMCI | ||||||||
Relational > Item | Inferior Temporal Gyrus | L | 20 | −50 | −16 | −22 | 6.03 | 26 |
Middle Frontal Gyrus | L | 9 | −32 | 52 | 24 | 5.28 | 44 | |
Superior Temporal Gyrus | L | 22 | −46 | −11 | 4 | 5.13 | 58 | |
R | 22 | 54 | −8 | 2 | 5.13 | 27 | ||
Item > Relational | Inferior Frontal Gyrus | R | 45 | 60 | 22 | 16 | 6.00 | 59 |
Precuneus | L | 7 | −18 | −40 | 52 | 4.98 | 27 | |
Superior Parietal Lobule | L | 7 | −24 | −58 | 50 | 4.23 | 20 | |
Normal Control > aMCI | ||||||||
Relational > Item | Precuneus | L | 7 | −16 | −56 | 38 | 4.35 | 195 |
Posterior Cingulate | R | 31 | 18 | −44 | 28 | 4.21 | 43 | |
Parahippocampal Cortex | R | 36 | 30 | −34 | −10 | 4.12 | 50 | |
Angular Gyrus | L | 39 | −48 | −62 | 16 | 4.10 | 79 | |
Item > Relational | Inferior Frontal Gyrus | R | 47 | 32 | 22 | −6 | 4.74 | 77 |
Superior Frontal Gyrus | R | 10 | 20 | 64 | 6 | 4.38 | 86 | |
Inferior Frontal Gyrus | R | 47 | 30 | 12 | −14 | 4.14 | 28 | |
aMCI > Normal Control | ||||||||
Relational > Item | Superior Temporal Gyrus | L | 22 | −50 | −16 | 2 | 5.26 | 74 |
Supramarginal Gyrus | R | 40 | 64 | −28 | 20 | 4.14 | 52 | |
Item > Relational | Anterior Cingulate | R | 24 | 4 | 24 | 2 | 4.46 | 49 |
Inferior Frontal Gyrus | R | 45 | 60 | 22 | 18 | 4.39 | 64 | |
Normal Control AND aMCI | ||||||||
Relational > Item | Superior Temporal Gyrus | R | 21 | 40 | 2 | −12 | 7.80 | 49 |
Item > Relational | Middle Frontal Gyrus | R | 10 | 46 | 46 | −12 | 6.33 | 32 |
Note. Regions significant at p < .005, k > 20. T = t-value; R = right; L = left; PHC = parahippocampal cortex; BA = approximate Brodmann area based on Montreal Neurological Institute coordinates.