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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Am J Reprod Immunol. 2013 Aug 1;71(1):10.1111/aji.12153. doi: 10.1111/aji.12153

Figure 1. Prostaglandin E2 inhibits class A scavenger receptor-dependent phagocytosis of unopsonized C. sordellii by THP-1 cells.

Figure 1

Cells were treated with the class A scavenger receptor antagonists (A) fucoidan, dextran sulfate, or the structurally similar negative control chondroitin sulfate for 30 min (n=3-4), or (B) PGE2 (n=6) for 15 min prior to challenge with FLUORC. sordellii as described in Materials and Methods. Phagocytosis was quantified by fluorometry. Data are mean ± SEM. **, p<0.01; ***, p<0.001 by ANOVA. (C) Cells were treated with PGE2 for 15 min before lysis with 0.1M HCl and cAMP measurement by EIA (n=12). Data are mean ± SEM. ****, p<0.0001 by Student paired t-test compared to untreated controls.