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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Am J Reprod Immunol. 2013 Aug 1;71(1):10.1111/aji.12153. doi: 10.1111/aji.12153

Figure 4. A conceptual model of PGE2 inhibition of vegetative C. sordellii phagocytosis by THP-1 cells.

Figure 4

Vegetative C. sordellii bacteria are phagocytosed via class A scavenger receptors (CASR). PGE2 stimulated intracellular cAMP synthesis by adenylate cyclase (AC) following ligation of the Gαs-coupled EP2 and EP4 receptors. The cAMP burst in turn activated the type I isoform of protein kinase A (PKA-RI), which is involved in suppressing the internalization of C. sordellii. Pharmacological tools used in these experiments include the EP2 agonist butaprost free acid (BFA), the EP2 agonist L-902,688, the EP2 antagonist AH-6809, the EP4 antagonists ONO AE1-208, and the PKA RI agonist 2-Cl-8-MA-cAMP.