Table 3.

Effect of hypoxia on islet secreted mediators by H/N ratios (fold increase by hypoxia).

	Encapsulated islets		Nonencapsulated islets
	Mean ± SEM	Median	Mean ± SEM	Median
IL-6	3.52 ± 0.80*	2.48	28.43 ± 24.22∗a	4.66
IL-9	0.97 ± 0.11	1.01	1.09 ± 0.17	0.95
IL-12	0.88 ± 0.07	0.93	0.69 ± 0.09∗#	0.71
IL-8	1.59 ± 0.23*	1.39	3.19 ± 0.79∗#	2.11
MCP-1	1.12 ± 0.09	0.98	1.40 ± 0.15∗#	1.31
VEGF	0.91 ± 0.06	0.88	0.70 ± 0.07∗#	0.72

*P < 0.001–0.05 for the effect of hypoxia, ^# P < 0.01–0.05 for the comparison of encapsulated versus non-encapsulated islets. Data are based on 11–13 single experiments (one sample per condition), one-five experiments per donor (five donors). ^aMean ± SEM contains one outlier value. Excluding the outlier changes mean ± SEM to 5.23 ± 1.19 and median to 4.14.

H/N equals ratio of hypoxic to normoxic conditions.