Figure 2.

Kinetic profiling of cell migration response. Time lapse images obtained from the IncuCyte platform demonstrating the polarity and morphology of migrating HT1080 fibrosarcoma cells following compound treatment. White arrow denotes direction of cell movement. The time resolved images clearly demonstrate the impact that compound X has upon the adhesive mechanisms regulating cell motility with clear defects in lamellipodia formation at the leading edge and uropod retraction at the trailing edge (Figure 2).