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. 2011 Jun 22;3(2):326–337. doi: 10.3390/pharmaceutics3020326

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — (A) The effects of drugs (alone or in combination) on the CAR of [³H]-3TC; (B) [³H]-ddI; (C) [³H]-TDF, (D) [³H]-ABC and (E) effects of 50 μM ABC on membrane-bound and intracellular [³H]-3TC, -ddI and -TDF in PBMCs isolated from blood buffy coats. Isolated PBMCs (5 × 10⁶ cells) were incubated (30–45 min, 4 °C, or 37C °C) in the absence or presence of the drugs (at concentrations indicated) before the assays were terminated as described in the methods section. Each bar represents mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control; n = 11. dC, deoxycytidine; dI, deoxyinosine; dG, deoxyguanosine.

Figure 1. — (A) The effects of drugs (alone or in combination) on the CAR of [³H]-3TC; (B) [³H]-ddI; (C) [³H]-TDF, (D) [³H]-ABC and (E) effects of 50 μM ABC on membrane-bound and intracellular [³H]-3TC, -ddI and -TDF in PBMCs isolated from blood buffy coats. Isolated PBMCs (5 × 10⁶ cells) were incubated (30–45 min, 4 °C, or 37C °C) in the absence or presence of the drugs (at concentrations indicated) before the assays were terminated as described in the methods section. Each bar represents mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control; n = 11. dC, deoxycytidine; dI, deoxyinosine; dG, deoxyguanosine.