Figure 1.

Degree of weight loss after LCMV infection of different HLH-prone mouse models depends on the affected gene. Mice were infected with 200 pfu LCMV i.v. Percent weight loss of initial body weight is depicted over the course of 12 days. Body weight of mutant mice (beige, pearl, souris, STX-11KO, ashen/filled circles) in comparison with wild-type (open circle) and PKO (open triangle) mice are shown. The graph depicted on the lower right illustrates a direct comparison of body weight loss of all mouse groups on day 12 after LCMV infection.