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. 2013 Dec 16;4:448. doi: 10.3389/fimmu.2013.00448

Figure 5.

Figure 5

Delayed HLH onset in patients with SYNTAXIN-11 and LYST deficiency compared with RAB27A- and PRF1-deficient patients. (A) Cumulative incidence and (B) age at onset of HLH in FHL2 (PRF1 deficiency, gray circles; n = 72), GS2 (RAB27A deficiency, gray triangles; n = 61), FHL4 (STX11 deficiency, open squares; n = 30), and CHS (LYST deficiency, black squares; n = 21) patients carrying null bi-allelic mutations, as detailed in Table 3. The incidence of HLH was analyzed with a log-rank test; *p < 0.05 for FHL4 vs. GS2 patients; ***p < 0.001 for GS2 vs. CHS patients; ****p < 0.0001 for FHL2 vs. GS2, FHL2 vs. FHL4 and FHL2 vs. CHS; ND = no statistical differences were observed between FHL4 vs. CHS patients. The onset of HLH was analyzed with a one-way ANOVA. *p < 0.05; ***p < 0.001; ***p < 0.0001. Mutations in PRF1, RAB27A, and STX11 are detailed in Ref. (44), and mutations in CHS1/LYST are detailed in Table 3.