Table A1.
Analysis of HLH biomarker on day 8 after LCMV infection.
| HLH parameter | Wild-type | Beige | Pearl | Souris | Syntaxin-11KO | Ashen | PKO |
|---|---|---|---|---|---|---|---|
| Ferritin (ng/mL) | 393.8 ± 244.0 | 493.9 ± 181.1 | 892.6 ± 424.6*** | 481.8 ± 259.4 | 365.0 ± 163.1 | 578.3 ± 79.7 | 1280.7 ± 1212.9*** |
| sCD25 (pg/mL) | 545.7 ± 206.2 | 508.0 ± 261.5 | 805.2 ± 294.5 | 816.4 ± 234.5 | 707.1 ± 389.7 | 916.7 ± 415.3 | 1060.4 ± 314.1* |
| Triglycerides (mg/dL) | 58.3 ± 18.0 | 97.1 ± 21.6 | 97.3 ± 93.3 | 63.5 ± 54.2 | 187.5 ± 97.0* | 174.0 ± 107.9 | 164.1 ± 90.1*** |
| Additional parameter | |||||||
| IFN-γ (ng/mL) | 0.4 ± 1.2 | 8.45 ± 9.9 | 20.5 ± 16.5* | 114.8 ± 26.0*** | 79.7 ± 60.6** | 70.3 ± 42.3* | 156.7 ± 56.8*** |
| HLH | NO | NO. | Transient | YES | YES | YES | Lethal |
Gray fields indicate fulfilled HLH criteria.
The red font accentuates the final disease phenotype.
***p < 0.001; **p < 0.01; *p < 0.05 (ANOVA; statistically significant differences compared to day 8 values of wild-type mice).