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. 2013 Nov 21;110(50):20278–20283. doi: 10.1073/pnas.1318031110

Fig. 2.

Fig. 2.

Fluorocitrate reduces sIPSC duration in the nRT, and this effect is blocked by the α3(H126R) mutation. (A) Representative continuous traces of sIPSCs recorded in nRT cells from WT C57BL/6 mice in control conditions (Left) and after FC treatment (Right). (B) Averaged sIPSCs from nRT cells from WT mice in control conditions (black trace) and after FC treatment (gray trace), normalized to peak amplitude. (C) Averaged sIPSCs from nRT cells from α3(H126R) mice in control conditions (dark-blue trace) and after FC treatment (light-blue trace), normalized to peak amplitude. (D) Mean ± SEM for sIPSC half-width in WT and α3(H126R) mice. (E) Probability distributions comparing sIPSC half-width in WT and α3(H126R) mice in control and FC-treated conditions (n = 1,000–2,200 events/group). (F and G) Mean ± SEM for sIPSC amplitude (F) and frequency (G) in WT and α3(H126R) mice. *P < 0.05, ***P < 0.001 vs. WT con (D, E, and G) or α3(H126R) con (G).