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. 2013 Aug 14;209(1):150–162. doi: 10.1093/infdis/jit420

Figure 6.

Figure 6.

Forty-day consecutive treatment with AN4169 and nifurtimox or intermittent dosing with nifutimox cures mice infected with Trypanosoma cruzi. A, Schematic representation of infection, treatment, and immunosuppression. B, Parasitemias in untreated and treated mice at 120 days postinfection, after administration of the immunosuppressant cyclophosphamide (days 100, 103, 106, 109, and 112). C, T. cruzi DNA isolated from skeletal muscle tissues of untreated or treated mice and suppressed with cyclophosphamide (20 days after suppression started) determined by quantitative reverse-transcription polymerase chain reaction. D, Detection of T. cruzi–specific CD8+ T cells in the blood of untreated and treated mice using the TSKB20-tetramer at 90 days postinfection (before cyclophosphamide suppression). E, Expression of CD127 in blood on the CD8+ T cells (naive) and on the CD8+ TSKB20-tetramer+ T cells from untreated and treated mice at 90 days postinfection. Data are representative of 10–11 mice per group. Abbreviations: dpi, days postinfection; NFX, nifurtimox; T. cruzi, Trypanosoma cruzi.