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A dose-response analysis showed a statistically significant effect of dose on osteoblastic activity markers (A) alkaline phosphatase (ALPase) activity (p = 0.0139) and (B) Von Kossa (p = 0.0352) staining after 4 weeks of culture. The doses are shown in ng/mL concentrations. The peak effect was seen for the 100-μg/mL dose and dropped off for higher doses. The bars in the diamond represent mean and 95% confidence intervals.
