Table 3 Therapies received and disease course on the basis of patient reports at follow-up (absolute and relative frequencies).

	Total (n = 2 492)	BP(−) (n = 2 056)	BP(+) (n = 436)	p value	Approved indication (n = 397)	Trial participation (n = 29)	Off-label use (n = 10)
Chemotherapy
NoYesNo data	1 100 (48.3)1 177 (51.7)215	941 (49.9)943 (50.1)172	159 (40.5)234 (59.5)43	0.001	158 (44.5)197 (55.5)42	0 (0.0)29 (100.0)0	1 (11.1)8 (88.9)1
Radiation
NoYesNo data	276 (11.1)2 215 (88.9)1	221 (10.8)1 834 (89.2)1	55 (12.6)381 (87.4)0	0.275	50 (12,6)347 (87,4)0	4 (13.8)25 (86.2)0	1 (10.0)9 (90.0)0
Antihormonal therapy (AHT)
NoYesNo data	392 (16.0)2 051 (84.0)49	319 (15.8)1 699 (84.2)38	73 (17.2)352 (82.8)11	0.513	58 (15,0)328 (85,0)11	9 (31.0)20 (69.0)0	6 (60.0)4 (40.0)0
Drugs of AHT
AIAI plus GnRH analoguesTAM 5 years, then AITAM 2 years, then AI 3 yearsTAMTAM plus GnRH analoguesNo data	1 026 (53.5)1 (< 0.1)4 (0.2)294 (15.3)409 (21.3)182 (9.5)135	813 (51.1)0 (0.0)4 (0.3)268 (16.9)357 (22.5)148 (9.3)109	213 (65.3)1 (0.3)0 (0.0)26 (8.0)52 (16.0)34 (10.4)26	< 0.001	204 (67.5)0 (0.0)0 (0.0)23 (7.6)44 (14.6)31 (10.3)26	7 (35.0)1 (5.0)0 (0.0)3 (15.0)7 (35.0)2 (10.0)9	2 (50.0)0 (0.0)0 (0.0)0 (0.0)1 (25.0)1 (25.0)6
Herceptin
NoYesNo data	2 202 (89.4)262 (10.6)28	1 825 (89.6)212 (10.4)19	377 (88.3)50 (11.7)9	0.437	344 (88.7)44 (11.3)9	24 (82.8)5 (17.2)0	9 (90.0)1 (10.0)0
Later recurrence
NoYesNo data	2 403 (98.3)41 (1.7)48	1 986 (98.5)30 (1.5)40	417 (97.4)11 (2.6)8	0.143	383 (98.2)7 (1.8)7	27 (96.4)1 (3.6)1	7 (70.0)3 (30.0)0
Later metastases
NoYesNo data	2 357 (96.5)85 (3.5)49	1 983 (98.3)34 (1.7)39	374 (87.8)51 (12.2)10	< 0.001	339 (87.4)49 (12.6)9	26 (92.9)2 (7.1)1	9 (90.0)1 (10.0)0
Localisation of metastases
BoneLiverLungsBrainPleuraBone marrowOther organsNo data	38 (47.0)10 (12.0)17 (20.5)9 (10.8)1 (1.2)1 (1.2)6 (7.2)3	5 (15.6)5 (15.6)13 (40.6)6 (18.8)0 (0.0)0 (0.0)3 (9.4)1	34 (66.7)5 (9.8)4 (7.8)3 (5.9)1 (2.0)1 (2.0)3 (5.9)0	< 0.001	33 (68.8)5 (10.4)4 (8.3)3 (6.2)0 (0.0)1 (2.1)2 (4.2)1	1 (50.0)0 (0.0)0 (0.0)0 (0.0)1 (50.0)0 (0.0)0 (0.0)0	0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (100.0)0