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Time course of nicotine (A) and cotinine (B) plasma concentration in mice pretreated with methoxsalen. Nicotine was administered orally (15mg/kg) 15min after pretreatment with ip (
) vehicle or (
) methoxsalen. Each timepoint represents the mean ± SEM of four to six animals. For the vehicle pretreatment, all values for nicotine plasma levels at 4 and 6hr were below the limits of detection.
