Table 1.

Pharmacokinetic Parameters of (A) Oral Nicotine and (B) Cotinine in Adult Male ICR Mouse After Pretreatment With <ethoxsalen

	Cmax (ng/ml)	AUC (ng · min/ml)	T1/2 (min)	CL/F (ml/min)
A
Saline/nicotine	64±12.6	60.8±24.7	26.5±9.6	102.8±3.5
Methoxsalen/nicotine	185±10.5a	373.7±24.7a	105.8±21.3a	16.7±3.3a
B
Saline/nicotine	460±43.8	957±55	117.3±39	6.5±0.8
Methoxsalen/nicotine	118±40a	385±55a	>1,050	16.2±0.8a

Note. AUC = area under the curve; CL = confidence level. Values are shown as mean ± SD (n = 4–6 per group).

^a p < .05 compared with saline/nicotine group.