Fig 4.

Representative traces showing acetylcholine concentration responses of controls and in the presence of 1 μM derquantel, 0.3 μM abamectin and the combination. Increasing concentrations of acetylcholine (0.3 - 30 μM) shown in black arrows were applied for 15s in controls. In test, the acetylcholine applications followed 30 min pretreatment of the preparations with the drugs. (A) Representative trace, one from 11 such experiments, shows a concentration dependent increase in the depolarizations to the acetylcholine applications in the controls. (B) Representative, one from 8 such experiments trace shows, a reduction in acetylcholine induced depolarizations in the presence of derquantel. (C) Representative trace, one from 9 such experiments shows a reduction in the acetylcholine induced depolarization in the presence of abamectin. (D) Representative trace, one from 7 such experiments shows a reduction in acetylcholine induced depolarizations in the presence of the combination.