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. Author manuscript; available in PMC: 2014 Oct 8.
Published in final edited form as: Structure. 2013 Aug 29;21(10):10.1016/j.str.2013.07.014. doi: 10.1016/j.str.2013.07.014

Figure 1. Electron microscopy analyses of the hGlyR-α1 TMD oligomeric complexes.

(a) A raw electron micrograph of negatively stained hGlyR-α1 TMD oligomers in LPPG (scale bar, 50 nm). Representative particles are indicated with red circles. (b) Selected 2D class averages of hGlyR-α1 TMD oligomers from 210 particle images. Class averages show doughnut-shaped particles with a central channel and several oligomeric states, including pentamer and tetramer. (c) Representative raw particle images corresponding to the pentameric (0-3) and tetrameric (5-7) configurations. An average of the raw particles from panel 0-3 is shown in panel 4. Panel 8 and 9 show side views of the particles. See also Figure S2.

Figure 1